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DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: dishevelled 1; dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1
基因别名: DRS2; DVL; dvl-1; DVL1; DVL1L1; DVL1P1; mKIAA4029
UniProt ID: (Human) O14640, (Rat) Q9WVB9, (Mouse) P51141
Entrez Gene ID: (Human) 1855, (Rat) 83721, (Mouse) 13542
分子生物学功能:
scaffold/adaptor protein
