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Invitrogen
DYNC1H1 Polyclonal Antibody
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DYNC1H1 Antibody (PA5-49373) in WB
Western blot analysis of DYNC1H1 in Hela, PC-3 cell line and rat brain tissue (left to right). Samples were probed with a DYNC1H1 polyclonal antibody (Product # PA5-49373) diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35 µg per lane.
产品信息
PA5-49373
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 4224-4257 amino acids from the C-terminal region of human DYNC1H1.
偶联物
形式
Liquid
浓度
0.29 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
Predicted to react with mouse based on sequence homology.
靶标信息
DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1) is a gene that encodes a protein belonging to the dynein family, which are motor proteins critical for various cellular processes. Dyneins are responsible for retrograde intracellular transport along microtubules, meaning they move cargo from the periphery of the cell towards the nucleus. The DYNC1H1 protein is a heavy chain component of cytoplasmic dynein 1, which plays a key role in the movement of organelles, vesicles, and other cellular components. Mutations in DYNC1H1 have been associated with several neurological disorders, including spinal muscular atrophy with lower extremity predominance (SMA-LED) and Charcot-Marie-Tooth disease type 2O (CMT2O). Research into DYNC1H1 continues to uncover its involvement in cellular mechanics and its implications in various genetic conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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