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Proteintech
Desmin Monoclonal Antibody (3E12C8)
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产品信息
60226-1-IG
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
3E12C8
抗原
Desmin Fusion Protein Ag9675 (121-470 aa encoded by BC032116)
偶联物
形式
Liquid
浓度
1.2 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NYIEKVRFL EQQNAALAAE VNRLKGREPT RVAELYEEEL RELRRQVEVL TNQRARVDVE RDNLLDDLQR LKAKLQEEIQ LKEEAENNLA AFRADVDAAT LARIDLERRI ESLNEEIAFL KKVHEEEIRE LQAQLQEQQV QVEMDMSKPD LTAALRDIRA QYETIAAKNI SEAEEWYKSK VSDLTQAANK NNDALRQAKQ EMMEYRHQIQ SYTCEIDALK GTNDSLMRQM RELEDRFASE ASGYQDNIAR LEEEIRHLKD EMARHLREYQ DLLNVKMALD VEIATYRKLL EGEESRINLP IQTYSALNFR ETSPEQRGSE VHTKKTVMIK TIETRDGEVV SEATQQQHEV L (121-470 aa encoded by BC032116)
靶标信息
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
