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Progen
Desmoglein 1/2 Monoclonal Antibody (DG 3.10)
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产品信息
61002PROGEN
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
DG 3.10
抗原
Band 3 Polypeptide Of Isolated Desmosomes From Bovine Muzzle Epidermis
偶联物
形式
Lyophilized
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 0.5% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute lyophilized product with 1 mL distilled water.
DG 3.10 recognizes desmoglein 1 + 2 (desmosome-specific cadherins) in desmosome-bearing cells; does not react with cells containing plaque-bearing junctions of non-desmosomal type. Tumors specifically detected: all epithelium-derived tumors, notably carcinomas, and meningiomas. Polypeptide reacting: MW 165 000 Desmoglein, "band 3" polypeptide of the desmosomal complex. Epitope recognized has been localized at the repeating unit domain ("RUD") of the cytoplasmic C-terminal part of the polypeptide.Reactivity on cultured cell lines: A-431, MDBK.
靶标信息
DSG1 (Desmoglein 1) is a Protein Coding gene. Diseases associated with DSG1 include Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige and Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse. Among its related pathways are Keratinization and Apoptotic execution phase. Gene Ontology (GO) annotations related to this gene include calcium ion binding and toxic substance binding. An important paralog of this gene is DSG4. DSG2 (Desmoglein 2) is a Protein Coding gene. Diseases associated with DSG2 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 and Cardiomyopathy, Dilated, 1Bb. Among its related pathways are Keratinization and Apoptotic execution phase. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication. An important paralog of this gene is DSG4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cadherin family member 4; Cadherin family member 5; desmoglein 1; desmoglein 1 beta; desmoglein 1 gamma; desmoglein 2; Desmoglein-1; Desmoglein-2; Desmosomal glycoprotein 1; DG1; DGI; DSG1; DSG1/2; DSG2; HDGC; Pemphigus foliaceus antigen
基因别名: CDHF4; CDHF5; DG1; DSG; DSG1; Dsg1b; Dsg1c; DSG2; EPKHE; EPKHIA; HDGC; PPKS1; SPPK1
UniProt ID: (Human) Q02413, (Bovine) Q03763, (Human) Q14126
Entrez Gene ID: (Human) 1828, (Bovine) 281131, (Human) 1829, (Bovine) 508151, (Rat) 291755, (Rat) 307562
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
single organismal cell-cell adhesion
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
response to progesterone
protein stabilization
maternal process involved in female pregnancy
desmosome organization
Purkinje myocyte development
cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
ventricular cardiac muscle cell action potential
bundle of His cell to Purkinje myocyte communication
