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Desmoplakin Antibody (711223) in ICC/IF
Immunofluorescence analysis was performed on fixed and permeabilized A-431 cells for detection of endogenous Desmoplakin /DSP using Anti-Desmoplakin /DSP Recombinant Rabbit Polyclonal Antibody (Product # 711223, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were sta... View More
产品信息
711223
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
14HCLC
抗原
Protein corresponding to Human DSP (aa 1970-2270)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2633135
产品详细信息
This antibody is predicted to react with Monkey, Cat and Mouse
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; Desmoplakin II; Desmoplakin-I; DP
基因别名: DCWHKTA; DP; DSP
UniProt ID: (Human) P15924
Entrez Gene ID: (Human) 1832
protein kinase C binding
structural molecule activity
structural constituent of cytoskeleton
protein binding
protein binding, bridging
poly(A) RNA binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
scaffold protein binding
intermediate filament binding protein
desmosome organization
ventricular compact myocardium morphogenesis
epidermis development
peptide cross-linking
keratinocyte differentiation
adherens junction organization
wound healing
intermediate filament organization
protein localization to adherens junction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
