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Invitrogen
Diacetoxyscirpenol Recombinant Mouse Monoclonal Antibody (3H10)
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Diacetoxyscirpenol Antibody (MA566555) in SDS-PAGE
SDS-PAGE characterization of Diacetoxyscirpenol under reducing conditions. Lane M: Protein marker (kDa); Lane DAS: Purified Diacetoxyscirpenol Recombinant Monoclonal (Product # MA566555). Diacetoxyscirpenol showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-360.
产品信息
MA566555
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3H10
抗原
Conjugate of DAS hapten and KLH.
偶联物
形式
Liquid
浓度
6.4 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Diacetoxyscirpenol (DAS) is a type of trichothecene mycotoxin produced by various species of Fusarium fungi, commonly found in contaminated grains and cereals. Structurally, DAS features an epoxy-sesquiterpene backbone with two acetoxy groups, contributing to its high biological activity and toxicity. The primary mechanism of DAS involves inhibition of protein synthesis in eukaryotic cells by binding to ribosomes and disrupting translation processes, leading to cytotoxic effects and cell death. In agricultural contexts, DAS contamination poses significant health risks to both humans and animals, including immunosuppression and gastrointestinal disturbances following ingestion of affected food sources. Due to its potency, ongoing research focuses on developing effective detection methods and mitigation strategies in food safety to reduce exposure. Additionally, regulatory bodies have set guidelines and limits for acceptable DAS levels in food and feed products to safeguard public health.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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