Invitrogen

Dicer Polyclonal Antibody

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说明书
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说明书
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产品信息

PA5-115124

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
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免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human DICER1(Accession Q9UPY3), corresponding to amino acid residues K1516-L1566.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2899760

产品详细信息

Antibody detects endogenous levels of total Dicer.

靶标信息

Dicer is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a means to specifically regulate the expression of target genes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: DCR; DCR-1; dicer 1 ribonuclease III; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; Dicer1, Dcr-1 homolog; double-strand-specific ribonuclease mDCR-1; Endoribonuclease Dicer; Helicase MOI; Helicase with RNase motif; helicase-moi

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基因别名: 1110006F08Rik; D12Ertd7e; DCR1; DICER; DICER1; Dicer1e; HERNA; K12H4.8-LIKE; KIAA0928; mKIAA0928; MNG1; RMSE2

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UniProt ID: (Human) Q9UPY3

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Entrez Gene ID: (Human) 23405, (Mouse) 192119, (Rat) 299284

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功能
double-stranded RNA binding helicase activity endoribonuclease activity ribonuclease III activity deoxyribonuclease I activity protein binding ATP binding protein domain specific binding siRNA binding metal ion binding pre-miRNA binding nucleotide binding nucleic acid binding RNA binding nuclease activity endonuclease activity hydrolase activity endoribonuclease activity, producing 5'-phosphomonoesters miRNA binding molecular_function
参与通路
negative regulation of transcription from RNA polymerase II promoter meiotic spindle organization angiogenesis regulation of protein phosphorylation hair follicle development apoptotic DNA fragmentation RNA processing cell proliferation regulation of Notch signaling pathway post-embryonic development zygote asymmetric cell division regulation of gene expression negative regulation of Schwann cell proliferation positive regulation of gene expression regulation of muscle cell apoptotic process positive regulation of Schwann cell differentiation myoblast differentiation involved in skeletal muscle regeneration rRNA catabolic process stem cell population maintenance spinal cord motor neuron differentiation nerve development olfactory bulb interneuron differentiation cerebral cortex development lung development embryonic limb morphogenesis production of siRNA involved in RNA interference targeting of mRNA for destruction involved in RNA interference gene silencing by RNA pre-miRNA processing hair follicle morphogenesis regulation of myelination positive regulation of myelination peripheral nervous system myelin formation conversion of ds siRNA to ss siRNA involved in RNA interference siRNA loading onto RISC involved in RNA interference embryonic hindlimb morphogenesis production of miRNAs involved in gene silencing by miRNA multicellular organism growth miRNA loading onto RISC involved in gene silencing by miRNA conversion of ds siRNA to ss siRNA regulation of odontogenesis of dentin-containing tooth regulation of viral genome replication regulation of cell differentiation regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter mRNA stabilization spleen development digestive tract development reproductive structure development regulation of oligodendrocyte differentiation epidermis morphogenesis branching morphogenesis of an epithelial tube neuron projection morphogenesis anatomical structure development regulation of neurogenesis cartilage development spindle assembly regulation of RNA metabolic process defense response to virus regulation of cell cycle cardiac muscle cell development inner ear receptor cell development negative regulation of glial cell proliferation intestinal epithelial cell development cardiac neural crest cell development involved in outflow tract morphogenesis ganglion development regulation of enamel mineralization hair follicle cell proliferation RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic regulation of miRNA metabolic process positive regulation of miRNA metabolic process biological_process
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