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Invitrogen
Dynactin 1 Recombinant Rabbit Monoclonal Antibody (PSH13-45)
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图: 1 / 16
Dynactin 1 Antibody (MA562925) in ICC/IF
Immunofluorescence analysis of Dynactin 1 was performed using SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Dynactin 1 Recombinant Rabbit Monoclonal Antibody (PSH13-45) (Product # MA562925) at 1:100 in 0.1% BSA, incubated at 4 degree celsius o... View More
产品信息
MA562925
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH13-45
抗原
Recombinant protein within human DCTN1 aa 1,051-1,278.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: HeLa cell lysate, HEK-293 cell lysate, SH-SY5Y cell lysate, Neuro-2a cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, human brain tissue, mouse brain tissue, HEK-293, Neuro-2a, PC-12.
Tissue Specificity: Low tissue specificity
Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, spindle, Nucleus envelope, cell cortex.
Sequence Similarities: 95% Mouse/Rat
Predicted band size: 142 kDa
靶标信息
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DP 150; DP-150; DP150; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; Dynactin subunit 1; Dynactin1; HMN7B; OTTHUMP00000202491; p135; p150 glued; p150 glued homolog; p150-glued; p150glued; unnamed protein product
基因别名:
AL022633; DAP-150; DCTN1; DP-150; Glued; HMND14; P135; p150; p150
UniProt ID: (Human) Q14203, (Rat) P28023, (Mouse) O08788
Entrez Gene ID: (Human) 1639, (Rat) 29167, (Mouse) 13191
establishment of mitotic spindle orientation
mitotic cell cycle
nuclear migration
nervous system development
neuromuscular junction development
centriole-centriole cohesion
ventral spinal cord development
positive regulation of microtubule polymerization
melanosome transport
microtubule anchoring at centrosome
retrograde transport, endosome to Golgi
neuromuscular process
nuclear envelope disassembly
cell division
regulation of mitotic spindle organization
motor behavior
neuron cellular homeostasis
positive regulation of microtubule nucleation
axonal transport
maintenance of synapse structure
positive regulation of neuromuscular junction development
non-motile cilium assembly
neuron projection maintenance
microtubule-based process
metabolic process
transport along microtubule
cytoplasmic microtubule organization
positive regulation of intracellular protein transport
transport
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