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Invitrogen
E-selectin Monoclonal Antibody (UZ4)
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产品信息
MA1-06504
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rat
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
UZ4
抗原
LPS-activated mlEND1 cells expressing E-selectin at their cell surface.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-06504 detects E-selectin in human and mouse samples.
MA1-06504 has sucessfully been used in Western blotting, flow cytometry, immunoprecipitation and IF. This antibody is not suitable for use in IHC on frozen tissue sections.
The MA1-06504 immunogen is LPS-activated mlEND1 cells expressing E-selectin at their cell surface.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
靶标信息
Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD62 antigen-like family member E; CD62E; e selectin; E-selectin; ELAM-1; endothelial adhesion molecule 1; Endothelial leukocyte adhesion molecule 1; LECAM2; leukocyte endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2
基因别名: CD62E; E-selectin; ELAM; Elam-1; ELAM1; ESEL; LECAM2; SELE
UniProt ID: (Human) P16581, (Mouse) Q00690
Entrez Gene ID: (Human) 6401, (Mouse) 20339
positive regulation of receptor internalization
leukocyte migration involved in inflammatory response
inflammatory response
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
activation of phospholipase C activity
calcium-mediated signaling
actin filament-based process
response to lipopolysaccharide
response to tumor necrosis factor
regulation of inflammatory response
leukocyte migration
leukocyte tethering or rolling
response to interleukin-1
positive regulation of leukocyte migration
cell adhesion
signal transduction
