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Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.
蛋白别名: DKFZp686C18211; E2F-3; MGC104598; RP1-177P22.2; Transcription factor E2F3
基因别名: E2F-3; E2F3; E2f3a; E2F3b; KIAA0075; RGD1561600