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Immunogen sequence: ETAVAPSLVA PALNKPKKPL TSSSAAPQRP ISTQRTAAAP KAGPGVVRKN PGVGNGDDEA AELMQQVNVL KLTVEDLEKE RDFYFGKLRN IELICQENEG ENDPVLQRIV DILYATDEGF VIPDEGGPQE EQEEY; Positive Samples: B-cell, U-87MG, LO2, HT-29, NIH/3T3, Mouse lung, Mouse spleen, Rat heart; Cellular Location: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
EB1 family proteins are evolutionarily conserved proteins that bind microtubule plus-ends and centrosomes and regulate the dynamics and organization of microtubules. The MAPRE genes encode the EB1 family proteins. The human MAPRE genes MAPRE1, MAPRE2, and MAPRE3 code for EB1, RP1, and EBF3 proteins, respectively. EB1 family members appear to be expressed ubiquitously. The EB1 (MAPRE1) gene, at 20q11. 2, is fused to MLL in an adult patient with pro-B acute lymphoblastic leukemia. EB1 is a microtubule-associated protein that interacts with the colorectal adenomatous polyposis coli tumor-suppressor protein and plays important roles in regulating microtubule dynamics, cell polarity, and chromosome stability.
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Protein Aliases: adenomatosis polyposis coli binding protein Eb1; adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; EB1; End-binding protein 1; MGC117374; MGC129946; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein, RP/EB family, member 1
Gene Aliases: 5530600P05Rik; AI462499; AI504412; AW260097; BIM1p; D2Ertd459e; EB1; MAPRE1
Molecular Function: non-motor microtubule binding protein