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Abnova
EDN2 Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00001907-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EDN2 (NP_001947.1, 1 a.a. approximately 178 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS CSSWLDKECV YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS ARDPACATFC LRRPWTEAGA VPSRKSPADV FQTGKTGATT GELLQRLRDI STVKSLFAKR QQEAMREPRS THSRWRKR
靶标信息
Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. The secreted peptide (~2kD, 21 amino acids) is produced as a result of endothelin-2 precursor (~20 kD) processing and functions as a ligand for endothelin receptors which upon peptide binding modulates a wide array of cell signaling events. Diseases associated with endothelins include aortic disease and patent ductus arteriosus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EDN 2; EDN-2; PP ET-2; preproendothelin 2
基因别名: ET-2; ET2; PPET2
UniProt ID: (Human) P20800
Entrez Gene ID: (Human) 1907
angiogenesis
vasculature development
positive regulation of leukocyte chemotaxis
hormonal regulation of the force of heart contraction
positive regulation of the force of heart contraction by chemical signal
regulation of systemic arterial blood pressure by endothelin
cellular calcium ion homeostasis
cell surface receptor signaling pathway
positive regulation of cell proliferation
cell tip growth
positive regulation of heart rate
artery smooth muscle contraction
vein smooth muscle contraction
cytokine-mediated signaling pathway
regulation of vasoconstriction
neutrophil chemotaxis
neuron projection development
positive regulation of prostaglandin biosynthetic process
macrophage activation
vasoconstriction
endothelial cell migration
positive regulation of smooth muscle contraction
macrophage chemotaxis
axon extension
positive regulation of calcium-mediated signaling
endothelin receptor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
