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Proteintech
EEF2K Polyclonal Antibody
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产品信息
13510-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EEF2K Fusion Protein Ag4432 (376-725 aa encoded by BC032665)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LSENSGDEN MSDVTFDSLP SSPSSATPHS QKLDHLHWPV FSDLDNMASR DHDHLDNHRE SENSGDSGYP SEKRGELDDP EPREHGHSYS NRKYESDEDS LGSSGRVCVE KWNLLNSSRL HLPRASAVAL EVQRLNALDL EKKIGKSILG KVHLAMVRYH EGGRFCEKGE EWDQESAVFH LEHAANLGEL EAIVGLGLMY SQLPHHILAD VSLKETEENK TKGFDYLLKA AEAGDRQSMI LVARAFDSGQ NLSPDRCQDW LEALHWYNTA LEMTDCDEGG EYDGMQDEPR YMMLAREAEM LFTGGYGLEK DPQRSGDLYT QAAEAAMEAM KGRLANQYYQ KAEEAWAQME E (376-725 aa encoded by BC032665)
靶标信息
EEF2K is a highly conserved Serine/Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer. EEF2K (eukaryotic elongation factor 2 kinase) is a threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Up activation, by a variety of upstream kinases including AMPK or TRPM7, EEF2K phosphorylates the elongation factor EEF2 at a single site. Then, EEF2K renders EEF2 unable to bind ribosomes and inactive - in turn, the rate of protein synthesis is reduced.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; EC 2.7.11.20; eEF-2 kinase; EF2K; elongation factor-2 kinase; euk; eukaroytic elongation factor 2 kinase; Eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; kinase eEF2K
基因别名: eEF-2K; EEF2K; HSU93850
UniProt ID: (Human) O00418
Entrez Gene ID: (Human) 29904
response to ischemia
translational elongation
regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of apoptotic process
positive regulation of endocytosis
protein autophosphorylation
positive regulation of synapse assembly
positive regulation of dendritic spine morphogenesis
cellular response to calcium ion
cellular response to cAMP
cellular response to anoxia
cellular response to brain-derived neurotrophic factor stimulus
response to prolactin
