Search
Invitrogen
EGFR (E746-A750del) Recombinant Rabbit Monoclonal Antibody (HL363)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 1
EGFR (E746-A750del) Antibody (MA5-42357) in WB
Western blot analysis of EGFR (E746-A750del) in various whole cell extracts (30 µg). Sample was separated with 5% SDS-PAGE, incubated with monoclonal EGFR (E746-A750del) antibody (Product # MA5-42357) at a dilution of 1:500, and followed by HRP-conjugated anti-rabbit IgG.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-42357
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL363
抗原
The immunogen used to generate this antibody corresponds to human EGFR (E746-A750del).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; contains extracellular domain; epidermal growth factor receptor; epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; GIG40; HER1; membrane protein; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; unnamed protein product
基因别名: ERBB; ERBB1; ERRP; HER1; mENA; NISBD2; NNCIS; PIG61
UniProt ID: (Human) P00533
Entrez Gene ID: (Human) 1956
chromatin binding
double-stranded DNA binding
protein kinase activity
MAP kinase kinase kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
epidermal growth factor-activated receptor activity
protein binding
ATP binding
kinase activity
enzyme binding
kinase binding
protein phosphatase binding
protein tyrosine kinase activator activity
ubiquitin protein ligase binding
identical protein binding
cadherin binding
epidermal growth factor binding
actin filament binding
ATPase binding
MAPK cascade
ossification
positive regulation of protein phosphorylation
signal transduction
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
learning or memory
positive regulation of cell proliferation
negative regulation of macroautophagy
neuron differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of peptidyl-serine phosphorylation
positive regulation of toll-like receptor 9 signaling pathway
ERBB2-EGFR signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of phosphorylation
negative regulation of apoptotic process
positive regulation of MAPK cascade
protein kinase B signaling
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of epithelial cell proliferation
regulation of peptidyl-tyrosine phosphorylation
protein insertion into membrane
positive regulation of protein kinase B signaling
response to UV-A
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
positive regulation of protein kinase C signaling
positive regulation of canonical Wnt signaling pathway
cell-cell adhesion
positive regulation of cGAS/STING signaling pathway
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of protein localization to plasma membrane
negative regulation of cardiocyte differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
