Proteintech

EIF2AK2, PKR Polyclonal Antibody, CoraLite® Plus 488

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说明书
实验方案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

CL488-18244

应用
建议稀释比
已发表文章

免疫细胞化学 (ICC/IF)

1:50-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

EIF2AK2, PKR fusion protein Ag13010

偶联物

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

激发/发射光谱

493/522 nm

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

内含物

0.05% ProClin 300

保存条件

-20°C, store in dark

运输条件

Wet ice

产品详细信息

Immunogen sequence: MAGDLSAGF FMEELNTYRQ KQGVVLKYQE LPNSGPPHDR RFTFQVIIDG REFPEGEGRS KKEAKNAAAK LAVEILNKEK KAVSPLLLTT TNSSEGLSMG NYIGLINRIA QKKRLTVNYE QCASGVHGPE GFHYKCKMGQ KEYSIGTGST KQEAKQLAAK LAYLQILSEE TSVKSDYLSS GSFATTCESQ SNSLVTSTLA SESSSEGDFS ADTSEINSNS DSLNSSSLLM NGLRNNQRKA KRSLAPRFDL PDMKETKYTV DKRFGMDFKE IELIGSGGFG QVFKAKHRID GKTYVIKRVK YNNEKAEREV KALAKLDHVN IVHYNGCWDG FDYDPETSDD SLESSDYDPE NSKNSSRSKT KCLFIQMEFC DKGT

靶标信息

EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & malignancy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: double stranded RNA activated protein kinase; dsRNA-activated kinase; EC 2.7.11.1; eIF-2 alpha; eIF-2A protein kinase 2; eIF2a Kinase; eukaryotic translation initiation factor 2 alpha kinase 2; Eukaryotic translation initiation factor 2-alpha kinase 2; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; Interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; Interferon-inducible RNA-dependent protein kinase; MGC126524; OTTHUMP00000201320; P1/eIF-2A protein kinase; p68 kinase; PKR; protein kinase R; Protein kinase RNA-activated; protein kinase, interferon inducible double stranded RNA dependent; Protein kinase, interferon-inducible double stranded RNA dependent; protein phosphatase 1, regulatory subunit 83; Serine/threonine-protein kinase TIK; T-cell viral integration site; Tyrosine-protein kinase EIF2AK2

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基因别名: 2310047A08Rik; 4732414G15Rik; AI467567; AI747578; EIF2AK1; EIF2AK2; PKR; PPP1R83; PRKR; Tik

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UniProt ID: (Human) P19525, (Mouse) Q03963, (Rat) Q63184

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Entrez Gene ID: (Human) 5610, (Mouse) 19106, (Rat) 54287

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功能
double-stranded RNA binding protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding protein phosphatase type 2A regulator activity poly(A) RNA binding nucleotide binding RNA binding protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
activation of MAPKK activity positive regulation of cytokine production transcription, DNA-templated translation protein phosphorylation negative regulation of cell proliferation response to mechanical stimulus response to virus response to toxic substance regulation of translational initiation by eIF2 alpha phosphorylation negative regulation of translation peptidyl-tyrosine phosphorylation evasion or tolerance by virus of host immune response endoplasmic reticulum unfolded protein response response to lipopolysaccharide positive regulation of chemokine production positive regulation of stress-activated MAPK cascade response to vitamin E negative regulation of osteoblast proliferation regulation of protein phosphatase type 2A activity cellular response to amino acid starvation response to interferon-alpha positive regulation of apoptotic process negative regulation of apoptotic process response to exogenous dsRNA negative regulation of viral genome replication innate immune response protein autophosphorylation positive regulation of NF-kappaB transcription factor activity defense response to virus regulation of NLRP3 inflammasome complex assembly positive regulation of NIK/NF-kappaB signaling regulation of hematopoietic progenitor cell differentiation regulation of hematopoietic stem cell proliferation regulation of hematopoietic stem cell differentiation immune system process regulation of transcription, DNA-templated phosphorylation response to organic substance
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