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Proteintech
ELL Polyclonal Antibody
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产品信息
51044-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ELL Fusion Protein Ag0617 (1-500 aa encoded by BC049195)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAALKEDRS YGLSCGRVSD GSKVSVFHVK LTDSALRAFE SYRARQDSVS LRPSIRFQGS QGHISIPQPD CPAEARTFSF YLSNIGRDNP QGSFDCIQQY VSSHGEVHLD CLGSIQDKIT VCATDDSYQK ARQSMAQAEE ETRSRSAIVI KAGGRYLGKK VQFRKPAPGA TDAVPSRKRA TPINLASAIR KSGASAVSGG SGVSQRPFRD RVLHLLALRP YRKAELLLRL QKDGLTQADK DALDGLLQQV ANMSAKDGTC TLQDCMYKDV QKDWPGYSEG DQQLLKRVLV RKLCQPQSTG SLLGDPAASS PPGERGRSAS PPQKRLQPPD FIDPLANKKP RISHFTQRAQ PAVNGKLGVP NGREALLPTP GPPASTDTLS SSTHLPPRLE PPRAHDPLAD VSNDLGHSGR DCEHGEAAAP APTVRLGLPL LTDCAQPSRP HGSPSRSKPK KKSKKHKDKE RAAEDKPRAQ LPDCAPATHA TPGAPADTPG LNGTCSVSSV PT (1-500 aa encoded by BC049195)
靶标信息
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Eleven-nineteen lysine-rich leukemia protein; ELL gene (11-19 lysine-rich leukemia gene); elongation factor RNA polymerase II; protein phosphatase 1, regulatory subunit 68; RNA polymerase II elongation factor ELL; RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN)
基因别名: C19orf17; ELL; ELL1; MEN; PPP1R68
UniProt ID: (Human) P55199, (Mouse) O08856
Entrez Gene ID: (Human) 8178, (Mouse) 13716
in utero embryonic development
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
negative regulation of phosphatase activity
positive regulation of DNA-templated transcription, elongation
positive regulation of transcription elongation from RNA polymerase II promoter
snRNA transcription from RNA polymerase II promoter
snRNA transcription from RNA polymerase III promoter
positive regulation of transcription from RNA polymerase III promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
