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产品信息
PA5-64949
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
0.04-0.4 µg/mL | 查看1篇已发表文章 1篇已发表文章 |
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
已发表种属 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant Human ELL2 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.2 mg/mL |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2662007 |
产品详细信息
Immunogen sequence: HLTNRVPPTLN GHLNPTSEKS AAGLPLPPAA AAIPTPPPLP STYLPISHPP QIVNSNSNSP STPEGRGTQD LPVDSFSQND SIYEDQQDKY TSRTSLETLP PGSVLLKCPK PMEENHS
Highest antigen sequence identity to the following orthologs - mouse 84%, rat 83%.
靶标信息
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ELL-related RNA polymerase II, elongation factor; elongation factor RNA for polymerase II 2; elongation factor, RNA polymerase II, 2; RNA polymerase II elongation factor ELL2
基因别名: ELL2
