Invitrogen

ELP2 Polyclonal Antibody

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ELP2 Antibody in Western Blot (WB) — Western Blot analysis of ELP2 in extracts of various cell lines using ELP2 Polyclonal Antibody (Product # PA5-90765) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

产品信息

PA5-90765

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-

产品规格
种属反应	Human, Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human ELP2
偶联物	Unconjugated
形式	liquid
浓度	2.94 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.3, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2806229

产品详细信息

Immunogen sequence: QNTVNPREWT PEIVISGHFD GVQDLVWDPE GEFIITVGTD QTTRLFAPWK RKDQSQVTWH EIARPQIHGY DLKCLAMINR FQFVSGADEK VLRVFSAPRN FVENFCAITG QSLNHVLCNQ DSDLPEGATV PALGLSNKAV FQGDIASQPS DEEELLTSTG FEYQQVAFQP SILTEPPTED HLLQNTLWPE VQKLYGHGYE IFCVTCNSSK TLLASACKAA KKEHAAIILW NTTSWKQVQN LVFHSLTVTQ MAFSPNEKFL LAVSRDRTWS LWKKQDTISP EFEPVFSLFA FTNKITSVHS R; Positive Samples: Mouse brain, Mouse heart, Mouse kidney, Rat spleen; Cellular Location: Cytoplasm, Nucleus

靶标信息

ELP2 regulates the ligand-dependent activation of STAT3. The protein acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: elongation protein 2 homolog; Elongator complex protein 2; elongator protein 2; ELP2; SHINC-2; signal transducer and activator of transcription 3 interacting protein 1; signal transducer and activator of transcription interacting protein 1; STAT3-interacting protein 1; StIP1

基因别名: AU023723; ELP2; Epl2; SHINC-2; STATIP1; StIP; StIP1

UniProt ID: (Human) Q6IA86, (Mouse) Q91WG4, (Rat) Q496Z0

Entrez Gene ID: (Human) 55250, (Mouse) 58523, (Rat) 307545

功能

transcription, DNA-templated regulation of transcription, DNA-templated regulation of JAK-STAT cascade transcription elongation from RNA polymerase II promoter positive regulation of endopeptidase activity proteasome assembly negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter

参与通路

RNA polymerase II core binding transcriptional repressor activity, RNA polymerase II transcription factor binding protein kinase binding histone binding protein binding DNA binding endopeptidase activator activity