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Proteintech
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Immunogen sequence: MVRGRISRL SVRDVRFPTS LGGHGADAMH TDPDYSAAYV VIETDAEDGI KGCGITFTLG KGTEVVVCAV NALAHHVLNK DLKDIVGDFR GFYRQLTSDG QLRWIGPEKG VVHLATAAVL NAVWDLWAKQ EGKPVWKLLV DMDPRMLVSC IDFRYITDVL TEEDALEILQ KGQIGKKERE KQMLAQGYPA YTTSCAWLGY SDDTLKQLCA QALKDGWTRF KVKVGADLQD DMRRCQIIRD MIGPEKTLMM DANQRWDVPE AVEWMSKLAK FKPLWIEEPT SPDDILGHAT ISKALVPLGI GIATGEQCHN RVIFKQLLQA KALQFLQIDS CRLGSVNENL SVLLMAKKFE IPVCPHAGGV GLCELVQHLI IFDYISVSAS LENRVCEYVD HLHEHFKYPV MIQRASYMPP KDPGYSTEMK EESVKKHQYP DGEVWKKLLP AQEN
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Antisense RNA to thymidylate synthase; HSRTSBETA; L-fuconate dehydratase; Mitochondrial enolase superfamily member 1; rTS; rTS alpha; rTS beta
基因别名: ENOSF1; RTS; TYMSAS
UniProt ID: (Human) Q7L5Y1
Entrez Gene ID: (Human) 55556