Invitrogen

ENPP1 Polyclonal Antibody

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ENPP1 Antibody (PA5-17097) in WB

Western blot analysis of ENPP1 in extracts from rat KNRK and human HepG2 cells using ENPP1 polyclonal antibody (Product # PA5-17097).

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产品信息

PA5-17097

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫沉淀 (IP)

1:50

产品规格

种属反应

Human, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues surrounding Leu520 of human ENPP1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

162 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_10979019

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer.

Cancer discovery

Ruiz-Fernández de Córdoba B,Moreno H,Valencia K,Perurena N,Ruedas P,Walle T,Pezonaga-Torres A,Hinojosa J,Guruceaga E,Pineda-Lucena A,Abengózar-Muela M,Cochonneau D,Zandueta C,Martínez-Canarias S,Teijeira Á,Ajona D,Ortiz-Espinosa S,Morales X,Ortiz de Solórzano C,Santisteban M,Ramos-García LI,Guembe L,Strnad V,Heymann D,Hervás-Stubbs S,Pío R,Rodríguez-Ruiz ME,de Andrea CE,Vicent S,Melero I,Lecanda F,Martínez-Monge R

Published figure using ENPP1 polyclonal antibody (Product # PA5-17097) in Western Blot

Mon May 02 00:00:00 UTC 2022

Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases.

Frontiers in physiology

Aresta Branco MSL,Gutierrez Cruz A,Dayton J,Perrino BA,Mutafova-Yambolieva VN

PA5-17097 was used in Simple Western - Size to examine possible mechanosensitive mechanisms of ATP hydrolysis in the LP by determining the degradation of 1,N 6 -etheno-ATP (eATP) at the anti-luminal side of nondistended (empty) or distended (full) murine (C57BL/6J) detrusor-free bladder model, using HPLC.

Sat Jul 16 00:00:00 UTC 2022

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner.

Metabolites

Gutierrez Cruz A,Aresta Branco MSL,Perrino BA,Sanders KM,Mutafova-Yambolieva VN

PA5-17097 was used in Simple Western - Size to find that soluble nucleotidases (s-NTDs) are released in the lumen of ex vivo mouse detrusor-free bladders.

Sat Dec 24 00:00:00 UTC 2022

生物信息学

蛋白别名: alkaline phosphodiesterase 1; Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; Ly-41 antigen; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1

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基因别名: ARHR2; COLED; ENPP1; M6S1; NPP1; NPPS; PC-1; PC1; PCA1; PDNP1

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UniProt ID: (Human) P22413, (Rat) Q924C3

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Entrez Gene ID: (Human) 5167, (Rat) 85496

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功能