NeoBiotechnologies

ER-beta (Estrogen Receptor beta-2) Monoclonal Antibody (ESR2/9710)

查看其他7个Estrogen Receptor beta-2抗体

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产品信息

2100-MSM20-P1

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

ESR2/9710

抗原

Recombinant fragment (around aa 1-200) of human ESR2 protein (exact sequence is proprietary).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product cellular localization: Nucleus.

Positive control: MCF-7 cells. Human breast, ovary or testis tissue.

Tissue specificity: Expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Expressed in the testis. Expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.

靶标信息

This MAb recognizes the estrogen receptor beta 2 isoform, expressed in cell nuclei of a range of human tissues including ovary, placenta, testis and vas deferens. No cross-reactivity is seen with estrogen receptor beta 1 isoform. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ER beta; ER-beta; Estrogen Receptor 2; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2

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基因别名: ER-BETA; Erb; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2

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UniProt ID: (Human) O75584

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Entrez Gene ID: (Human) 2100

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功能
core promoter sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding protein binding drug binding zinc ion binding enzyme binding estrogen receptor activity estrogen response element binding RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding peroxisome proliferator activated receptor binding receptor antagonist activity estradiol binding steroid hormone binding
参与通路
negative regulation of transcription from RNA polymerase II promoter ovarian follicle development behavioral fear response regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter signal transduction cell-cell signaling learning or memory response to water deprivation response to activity response to insecticide cerebellum development amygdala development hypothalamus development negative regulation of cell growth intracellular estrogen receptor signaling pathway prostate gland development response to nutrient levels response to testosterone response to genistein cellular response to drug positive regulation of apoptotic process regulation of neuron apoptotic process response to estrogen response to human chorionic gonadotropin estrous cycle response to ethanol positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity Sertoli cell development Sertoli cell proliferation positive regulation of ERK1 and ERK2 cascade cellular response to magnetism cellular response to estradiol stimulus response to dexamethasone extracellular negative regulation of signal transduction negative regulation of neuron death response to salt response to bisphenol A negative regulation of feeding behavior negative regulation of reactive oxygen species metabolic process
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