FIGURE: 1 / 1
Immunogen sequence: EIALEQKKEE CLKMESQLKK AHEAALEARA SPEMSDRIQH LEREITRYKD ESSKAQAEVD RLLEILKEVE NEKNDKDKKI AELERQVKDQ NKKVANLKHK EQVEKKKSAQ MLEEARRRED NLNDSSQQLQ DSLRKKDDRI EELEEALRES V; Positive Samples: HepG2, Jurkat, NIH/3T3, Rat brain; Cellular Location: Cytoplasm, Golgi apparatus membrane, Membrane, Peripheral membrane protein
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CAST2; CAZ-associated structural protein 2; ELKS/Rab6-interacting/CAST family member 1; ERC protein 1; ERC-1; FLJ31750; MGC12974; OTTHUMP00000160633; RAB6 interacting protein 2; RAB6-interacting protein 2; RIM-Binding Protein
Gene Aliases: 4930404L01Rik; 5033405M01Rik; 9630025C19Rik; B430107L16Rik; CAST; CAST2; ELKS; ERC; ERC-1; ERC1; ERC1b; KIAA1081; mKIAA1081; RAB6IP2; RAB6IP2A; RAB6IP2B
Molecular Function: membrane traffic protein