Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
ERCC1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
14586-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ERCC1 Fusion Protein Ag6112 (1-323 aa encoded by BC052813)
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDPGKDKEG VPQPSGPPAR KKFVIPLDED EVPPGVAKPL FRSTQSLPTV DTSAQAAPQT YAEYAISQPL EGAGATCPTG SEPLAGETPN QALKPGAKSN SIIVSPRQRG NPVLKFVRNV PWEFGDVIPD YVLGQSTCAL FLSLRYHNLH PDYIHGRLQS LGKNFALRVL LVQVDVKDPQ QALKELAKMC ILADCTLILA WSPEEAGRYL ETYKAYEQKP ADLLMEKLEQ DFVSRVTECL TTVKSVNKTD SQTLLTTFGS LEQLIAASRE DLALCPGLGP QKVRALGKNP RSWGKERAPN KHNLRPQSFK VKKEPKTRHS GFRL (1-323 aa encoded by BC052813)
靶标信息
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
基因别名: COFS4; Ercc-1; ERCC1; RAD10; UV20
UniProt ID: (Human) P07992, (Mouse) P07903
Entrez Gene ID: (Human) 2067, (Rat) 292673, (Mouse) 13870
single-stranded DNA endodeoxyribonuclease activity
TFIID-class transcription factor binding
damaged DNA binding
single-stranded DNA binding
protein binding
protein C-terminus binding
protein domain specific binding
structure-specific DNA binding
molecular_function
TBP-class protein binding
DNA binding
nuclease activity
endonuclease activity
hydrolase activity
endodeoxyribonuclease
pyrimidine dimer repair by nucleotide-excision repair
replicative cell aging
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
double-strand break repair
DNA recombination
mitotic recombination
syncytium formation
response to oxidative stress
spermatogenesis
response to nutrient
cell proliferation
male gonad development
UV protection
response to sucrose
response to X-ray
multicellular organism aging
negative regulation of telomere maintenance
nucleotide-excision repair, DNA incision
post-embryonic hemopoiesis
multicellular organism growth
interstrand cross-link repair
isotype switching
oogenesis
embryonic organ development
global genome nucleotide-excision repair
t-circle formation
positive regulation of t-circle formation
DNA catabolic process, endonucleolytic
cellular response to DNA damage stimulus
germ cell development
cell development
chromosome organization
