Invitrogen

ERI1 Monoclonal Antibody (OTI1B3)

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ERI1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry was performed on paraffin-embedded carcinoma of human bladder tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a ERI1 monoclonal antibody (Product # MA5-25827).

ERI1 Antibody in Western Blot (WB) — Western blot analysis of ERI1 in HEK293T cells in untransfected (Left lane) and transfected (Right lane) samples using 5 µg per lane. The samples were separated by SDS-PAGE and probed with ERI1 (Product # MA5-25827) monoclonal antibody.

产品信息

MA5-25827

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-
免疫组化（石蜡） (IHC (P))	1:150	-

产品规格
种属反应	Human, Non-human primate, Rat
宿主/亚型	Mouse / IgG2b
分类	Monoclonal
类型	Antibody
克隆号	OTI1B3
抗原	Full length human recombinant protein of ERI1 produced in HEK293T cell
偶联物	Unconjugated
形式	Liquid
浓度	1.1 mg/mL
纯化类型	Affinity Chromatography
保存液	PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物	0.02% sodium azide
保存条件	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2724263

靶标信息

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 3 ' exoribonuclease; 3' exoribonuclease; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; enhanced RNAi three prime mRNA exonuclease homolog 1; Eri-1 homolog; HEXO; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; protei; Protein 3'hExo; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1

基因别名: 3'EXO; 3'HEXO; ERI1; HEXO; RGD1308378; THEX1

UniProt ID: (Human) Q8IV48, (Rat) Q5FVR4

Entrez Gene ID: (Human) 90459, (Rat) 361159

分子生物学功能: exoribonuclease