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Proteintech
ETV6 Polyclonal Antibody
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产品信息
13182-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ETV6 Fusion Protein Ag3852 (1-355 aa encoded by BC043399)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MSETPAQCS IKQERISYTP PESPVPSYAS STPLHVPVPR ALRMEEDSIR LPAHLRLQPI YWSRDDVAQW LKWAENEFSL RPIDSNTFEM NGKALLLLTK EDFRYRSPHS GDVLYELLQH ILKQRKPRIL FSPFFHPGNS IHTQPEVILH QNHEEDNCVQ RTPRPSVDNV HHNPPTIELL HRSRSPITTN HRPSPDPEQR PLRSPLDNMI RRLSPAERAQ GPRPHQENNH QESYPLSVSP MENNHCPASS ESHPKPSSPR QESTRVIQLM PSPIMHPLIL NPRHSVDFKQ SRLSEDGLHR EGKPINLSHR EDLAYMNHIM VSVSPPEEHA MPIGRIADCR LLWDYVYQLL SDSRYE (1-355 aa encoded by B C043399)
靶标信息
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and Maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CGI-108; CSL4; Csl4p; ETS translocation variant 6; ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; hCsl4p; p13; RP11-452K12.9; SKI4; Ski4p; Tel; TEL1 oncogene; Transcription factor ETV6
基因别名: AW123102; AW557856; ETV6; TEL; TEL/ABL; TEL1; THC5
UniProt ID: (Human) P41212, (Mouse) P97360
Entrez Gene ID: (Human) 2120, (Mouse) 14011, (Rat) 312777
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
hematopoietic stem cell proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
