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Product Details
MA5-21342
Applications
Tested Dilution
Publications
产品规格
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B3
Immunogen
EXOSC8 (NP_852480.1, 177 a.a. ~ 276 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
形式
Liquid
浓度
0.2-1.0 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2606171
Product Specific Information
Peptide Sequence: AEVNLKKKSY LNIRTHPVAT SFAVFDDTLL IVDPTGEEEH LATGTLTIVM DEEGKLCCLH KPGGSGLTGA KLQDCMSRAV TRHKEVKKLM DEVIKSMKPK
Target Information
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: CBP-interacting protein 3; Exosome complex component RRP43; exosome complex exonuclease RRP43; Exosome component 8; OIP-2; Opa interacting protein 2; Opa-interacting protein 2; p9; Ribosomal RNA-processing protein 43; RP11-421P11.3
Gene Aliases: bA421P11.3; CIP3; EAP2; EXOSC8; OIP2; p9; PCH1C; RRP43; Rrp43p
UniProt ID: (Human) Q96B26
Entrez Gene ID: (Human) 11340
Molecular Function:
RNA metabolism protein
exoribonuclease
nucleic acid metabolism protein
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA processing
biological_process
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U1 snRNA 3'-end processing
U4 snRNA 3'-end processing
U5 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
nuclear mRNA surveillance
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear polyadenylation-dependent mRNA catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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