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Invitrogen
Emerin Polyclonal Antibody
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产品信息
PA1-5770
产品规格
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Rat emerin residues 114-183 (GST tag at N-terminus).
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PA1-5770 detects Emerin in rodent samples.
PA1-5770 has been successfully used in Western blot and immunofluorescence procedures.
The PA1-5770 immunogen is rat emerin residues 114-183 (GST tag a N-terminus).
靶标信息
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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