Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Endophilin B1/B2 Monoclonal Antibody (807009)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA5-61825
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
807009
抗原
E. coli-derived recombinant human Endophilin B1/Bif-1, Ala33-Asn189
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
Endophilin B1 (SH3GLB1) and Endophilin B2 (SH3GLB2) are genes that encode proteins belonging to the endophilin family, which are involved in various cellular processes, particularly those related to membrane dynamics and vesicular trafficking. These proteins are characterized by their SH3 domains, which facilitate interactions with other proteins, and their BAR domains, which bind to and shape cellular membranes. Endophilin B1 and B2 play crucial roles in the regulation of endocytosis, autophagy, and mitochondrial dynamics. They are especially important in the maintenance of mitochondrial integrity and function, as well as in the formation of autophagosomes, which are essential for the degradation and recycling of cellular components. Dysregulation or mutations in these genes can lead to impaired autophagy and mitochondrial dysfunction, contributing to the pathogenesis of various diseases, including neurodegenerative disorders like Parkinson's and Alzheimer's disease, and certain cancers. Research into Endophilin B1 and B2 provides valuable insights into their roles in cellular homeostasis and offers potential therapeutic targets for conditions involving defective membrane trafficking and autophagy. Understanding their mechanisms and interactions is key to developing strategies to modulate their activity for therapeutic benefit.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
