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Immunogen sequence: ALTEEAAVTVT PPITAQQGNW TVNKTEADNI EGPIALKFSH LCLEDHNSYC INGACAFHHE LEKAICRCFT GYTGERCEHL TLTSYAVDSY E
Highest antigen sequence identity to the following orthologs - mouse 83%, rat 80%.
Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. It is produced in several tissues, including the testis, liver, and heart, as well as in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EPG; Epigen; Epithelial mitogen; epithelial mitogen homolog
基因别名: ALGV3072; EPG; EPGN; PRO9904; UNQ3072/PRO9904
UniProt ID: (Human) Q6UW88
Entrez Gene ID: (Human) 255324
分子生物学功能: growth factor