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Invitrogen
EpoR Polyclonal Antibody
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产品信息
PA1-20180
产品规格
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant, full length, human EPO receptor, expressed in mouse myeloma NSO cells.
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
产品详细信息
PA1-20180 detects EPO Receptor in human samples.
PA1-20180 has been successfully used in ELISA and Western blot procedures. Western blot detects a band of ~50 kDa.
The PA1-20180 immunogen is recombinant, full length, human EPO receptor, expressed in mouse myeloma NSO cells.
靶标信息
EpoR encodes the erythropoietin receptor, which belongs to the cytokine receptor family. When erythropoietin binds to this receptor, it activates the Jak2 tyrosine kinase, which in turn activates various intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. The stimulated erythropoietin receptor plays a role in the survival of erythroid cells. Defects in this gene may result in erythroleukemia and familial erythrocytosis. Dysregulation of this gene may also affect the growth of certain tumors. Multiple transcript variants are produced as a result of alternate splicing. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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