Invitrogen

Estrogen Receptor beta Polyclonal Antibody

17个已发表图片
24 篇参考文献
查看其他34个Estrogen Receptor beta抗体

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说明书
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问题与答案
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产品信息

51-7700

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-2 µg/mL
查看11篇已发表文章 11篇已发表文章

免疫组化 (IHC)

-
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免疫组化（冰冻） (IHC (F))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

-
查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

-
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酶联免疫吸附实验 (ELISA)

1.0 µg/mL
-

免疫沉淀 (IP)

-
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其他PubMed (Misc)

-
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产品规格

种属反应

Human

已发表种属

Dog, Fish, Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A 19 amino acid synthetic peptide derived from the C-terminus of the human Estrogen Receptor-beta protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533915

靶标信息

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ER; ER beta; ER-beta; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; Nuclear receptor subfamily 3 group A member 2

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基因别名: ER-BETA; Erb; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2

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UniProt ID: (Human) O75584

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Entrez Gene ID: (Human) 2100

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功能
core promoter sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding protein binding drug binding zinc ion binding enzyme binding estrogen receptor activity estrogen response element binding RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding peroxisome proliferator activated receptor binding receptor antagonist activity estradiol binding steroid hormone binding
参与通路
negative regulation of transcription from RNA polymerase II promoter ovarian follicle development behavioral fear response regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter signal transduction cell-cell signaling learning or memory response to water deprivation response to activity response to insecticide cerebellum development amygdala development hypothalamus development negative regulation of cell growth intracellular estrogen receptor signaling pathway prostate gland development response to nutrient levels response to testosterone response to genistein cellular response to drug positive regulation of apoptotic process regulation of neuron apoptotic process response to estrogen response to human chorionic gonadotropin estrous cycle response to ethanol positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity Sertoli cell development Sertoli cell proliferation positive regulation of ERK1 and ERK2 cascade cellular response to magnetism cellular response to estradiol stimulus response to dexamethasone extracellular negative regulation of signal transduction negative regulation of neuron death response to salt response to bisphenol A negative regulation of feeding behavior negative regulation of reactive oxygen species metabolic process
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