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Product Details
PA5-50408
产品规格
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Fusion protein corresponding to a region derived from internal residues of human Fas apoptotic inhibitory molecule 3
Conjugate
Unconjugated
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
RRID
AB_2635861
Product Specific Information
The antibody detects endogenous levels of total Toso protein.
Target Information
Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: Fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc fragment receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; Regulator of Fas-induced apoptosis Toso
Gene Aliases: FAIM3; FCMR; TOSO
UniProt ID: (Human) O60667
Entrez Gene ID: (Human) 9214
Molecular Function:
immunoglobulin receptor superfamily
Performance Guarantee
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