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Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain.
Predicted reactivity: Mouse (91%), Rat (89%), Rhesus Monkey (98%).
IHC notes, Requires antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: down regulated by Ctnnb1, a; Down-regulated by CTNNB1 protein A; down-regulated by Ctnnb1, a; family with sequence similarity 126, member A; Hyccin
基因别名: AB030242; DRCTNNB1A; FAM126A; HCC; HLD5; HYCC1
UniProt ID: (Human) Q9BYI3, (Mouse) Q6P9N1
Entrez Gene ID: (Human) 84668, (Mouse) 84652