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Peptide sequence: HWTPCPSDTY AYRLLSGGGR SKYAKICFED NLLMGEQLGN VARGINIAIV
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 86%
FAM3B (family with sequence similarity 3, member B), also known as ORF9, C21orf11 or PANDER, is a 235 amino acid secreted protein that localizes to discrete vesicular and perinuclear structures. Expressed at high levels in pancreas and at lower levels in kidney, colon, testis, prostate and small intestine, FAM3B functions as an islet-specific cytokine that promotes apoptosis and may inhibit Insulin secretion from beta-cells, possibly playing a role in overall pancreatic activity. Human FAM3B shares 78% sequence identity with its mouse counterpart, suggesting a conserved role between species. Three isoforms of FAM3B, designated A, B and C, exist due to alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 21-Feb; Cytokine-like protein 2-21; D21M16SJHU19e; family with sequence similarity 3, member B; pancreatic derived factor; Pancreatic-derived factor; PANDER; Protein FAM3B
基因别名: 2-21; C21orf11; C21orf76; FAM3B; ORF9; PANDER; PRED44; UNQ320/PRO365
UniProt ID: (Human) P58499
Entrez Gene ID: (Human) 54097
分子生物学功能: antimicrobial response protein