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Proteintech
FAM49B Polyclonal Antibody
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产品信息
20127-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FAM49B Fusion Protein Ag13939 (1-324 aa encoded by BC003599)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGNLLKVLT CTDLEQGPNF FLDFENAQPT ESEKEIYNQV NVVLKDAEGI LEDLQSYRGA GHEIREAIQH PADEKLQEKA WGAVVPLVGK LKKFYEFSQR LEAALRGLLG ALTSTPYSPT QHLEREQALA KQFAEILHFT LRFDELKMTN PAIQNDFSYY RRTLSRMRIN NVPAEGENEV NNELANRMSL FYAEATPMLK TLSDATTKFV SENKNLPIEN TTDCLSTMAS VCRVMLETPE YRSRFTNEET VSFCLRVMVG VIILYDHVHP VGAFAKTSKI DMKGCIKVLK DQPPNSVEGL LNALRYTTKH LNDETTSKQI KSMLQ (1-324 aa encoded by BC003599)
靶标信息
Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CYFIP-related Rac1 interactor B; family with sequence similarity 49, member B; L1; Protein FAM49B
基因别名: 0910001A06Rik; AW122079; BM-009; CYRI; CYRIB; FAM49B; L1; RGD1307697
UniProt ID: (Human) Q9NUQ9, (Mouse) Q921M7
Entrez Gene ID: (Human) 51571, (Rat) 299909, (Mouse) 223601
