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Abnova
FARP2 Polyclonal Antibody, MaxPab™
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产品信息
H00009855-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FARP2 (AAH21301.1, 1 a.a. approximately 647 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGEIEGTYRV LQTAGMRLGA QTPVGVSTLE PGQTLLPRMQ EKHLHLRVKL LDNTMEIFDI EPKCDGQVLL TQVWKRLNLV ECDYFGMEFQ NTQSYWIWLE PMKPIIRQIR RPKNVVLRLA VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE ERLTCADTTA ALLTSHLLQS EIGDYDETLD REHLKVNEYL PGQQHCLEKI LEFHQKHVGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE GTKIQLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL GSRDECKNFW KICVEYHTFF RLLDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYFKDSGM KRIPYERRHS KTHTSVRALT ADLPKQSISF PEGLRTPASP SSANAFYSLS PSTLVPSGLP EFKDSSSSLT DPQVSYVKSP AAERRSGAVA GGPDTPSAQP LGPPALQPGP GLSTKSPQPS PSSRKSPLSL SPAFQVPLGP AEQGSSPLLS PVLSDAGGAG MDCEEPRHKR VPADEAYFIV KEILATERTY LKDLEVITVW FRSAVVKEDA MPATLMTLLF SNIDPIYEFH RGFLREVEQR LALWEGPSKA HTKGSHQRIG DILLRNMRQL KVFQLHEGHV AGVTKME
靶标信息
FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FERM domain including RhoGEF; FERM domain-including RhoGEF; FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2; FGD1-related Cdc42-GEF; FIR; PH domain-containing family C member 3; Pleckstrin homology domain-containing family C member 3
基因别名: FARP2; FIR; FRG; KIAA0793; PLEKHC3
UniProt ID: (Human) O94887
Entrez Gene ID: (Human) 9855
