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Invitrogen
FBXL20 Polyclonal Antibody
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产品信息
PA5-20486
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide near the amino terminus of the human SCRAPPER.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is A-20 cell lysate.
PA5-20486 can be used with blocking peptide PEP-0606.
靶标信息
Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: F-box and leucine-rich repeat protein 20; F-box protein FBL2; F-box/LRR-repeat protein 2-like; F-box/LRR-repeat protein 20; scrapper
基因别名: 2610511F20Rik; 4632423N09Rik; AI849362; AL117906; C86145; FBL2; Fbl20; Fbxl2; FBXL20; mKIAA4147; Scr
UniProt ID: (Human) Q96IG2, (Mouse) Q9CZV8
Entrez Gene ID: (Human) 84961, (Rat) 64039, (Mouse) 72194
