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Proteintech
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Immunogen sequence: DISVLQQQGS LSNTYLSKVD PDGKKIKQIQ QLFEEILSNS RQLKWLSCGF MLEIVTPTSL SSLSNAVANT MEHLSLLDNN IPGNSTLITA VELERFVNLH SLALDFCDFT AEMARVLTDS NHVPLQRLSL LVHNVSVMHK SLDNMPNDEH WKALSRKSTS FRVYIMAFDI KSEDMLKILK PSIPLERIHF DSYITCVSGA IVDLISRQYD KFLTHFILMN DVIDTSGFPD LSDNRNEDPL VLLAWRCTKL SLLAIHGYTV WAHNLIAIAR LRGSDLKVLE VTEESIDFDQ GELADQDVDP VHNLIEQVSL GLGQPWHAVM DIESLSVFTE PNRHFYREMQ SFSEDI
FBXO33 is the substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO33 probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1.Members of the F-box protein family, such as FBXO33, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AIG30-12-1; F-box only protein 33
基因别名: 5730501N20Rik; AI642135; BMND12; c14_5247; FBX33; FBXO33
UniProt ID: (Human) Q7Z6M2, (Mouse) Q8VE08
Entrez Gene ID: (Human) 254170, (Rat) 314157, (Mouse) 70611