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Proteintech
FDFT1 Polyclonal Antibody
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产品信息
13128-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FDFT1 Fusion Protein Ag3743 (1-358 aa encoded by BC029641)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MEFVKCLGH PEEFYNLVRF RIGGKRKVMP KMDQDSLSSS LKTCYKYLNQ TSRSFAAVIQ ALDGEMRNAV CIFYLVLRAL DTLEDDMTIS VEKKVPLLHN FHSFLYQPDW RFMESKEKDR QVLEDFPTIS LEFRNLAEKY QTVIADICRR MGIGMAEFLD KHVTSEQEWD KYCHYVAGLV GIGLSRLFSA SEFEDPLVGE DTERANSMGL FLQKTNIIRD YLEDQQGGRE FWPQEVWSRY VKKLGDFAKP ENIDLAVQCL NELITNALHH IPDVITYLSR LRNQSVFNFC AIPQVMAIAT LAACYNNQQV FKGAVKIRKG QAVTLMMDAT NMPAVKAIIY QYMEEIYHRI PDSDPSSSK (1-358 aa encoded by BC029641 )
靶标信息
FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SQS; Squalene synthase; squalene synthetase
基因别名: DGPT; ERG9; FDFT1; SQS; SS
UniProt ID: (Human) P37268
Entrez Gene ID: (Human) 2222
