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Proteintech
FDPS Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
16129-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FDPS Fusion Protein Ag9115 (68-419 aa encoded by BC010004)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.23 mg/mL
规格
34.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Western blot analysis using this antibody detected a major band around 41 kDa in mouse liver tissue.
Immunogen sequence: NGDQNSDVY AQEKQDFVQH FSQIVRVLTE DEMGHPEIGD AIARLKEVLE YNAIGGKYNR GLTVVVAFRE LVEPRKQDAD SLQRAWTVGW CVELLQAFFL VADDIMDSSL TRRGQICWYQ KPGVGLDAIN DANLLEACIY RLLKLYCREQ PYYLNLIELF LQSSYQTEIG QTLDLLTAPQ GNVDLVRFTE KRYKSIVKYK TAFYSFYLPI AAAMYMAGID GEKEHANAKK ILLEMGEFFQ IQDDYLDLFG DPSVTGKIGT DIQDNKCSWL VVQCLQRATP EQYQILKENY GQKEAEKVAR VKALYEELDL PAVFLQYEED SYSHIMALIE QYAAPLPPAV FLGLARKIYK RRK (68-419 aa encoded by BC010004)
靶标信息
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: (2E,6E)-farnesyl diphosphate synthase; cholesterol-regulated 39 kDa protein; cholesterol-regulated protein CR39; CR 39; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase (EC 2.5.1.1); farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; farnesyl-diphosphate synthase; Fdps; FPP synthase; FPP synthetase; FPS; geranyltranstransferase; KIAA1293; testis-specific farnesyl pyrophosphate synthetase; unnamed protein product
基因别名: 6030492I17Rik; Ac2-125; Fdpsl1; FPPS; FPS; mKIAA1293; POROK9
UniProt ID: (Human) P14324, (Mouse) Q920E5, (Rat) P05369
Entrez Gene ID: (Human) 2224, (Mouse) 110196, (Rat) 83791
cholesterol biosynthetic process
isoprenoid biosynthetic process
farnesyl diphosphate biosynthetic process, mevalonate pathway
geranyl diphosphate biosynthetic process
geranylgeranyl diphosphate biosynthetic process
zymosterol biosynthetic process
farnesyl diphosphate biosynthetic process
positive regulation of cholesterol biosynthetic process
positive regulation of cell growth involved in cardiac muscle cell development
spermatogenesis
male gonad development
response to xenobiotic stimulus
response to testosterone
response to peptide hormone
response to cholesterol
cellular response to fatty acid
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