Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
FGF23 Recombinant Rabbit Monoclonal Antibody (20H20L38)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 6
FGF23 Antibody (704970) in ICC/IF
Immunofluorescence analysis of FGF23 was performed using FGF23 Recombinant Rabbit Monoclonal Antibody (20H20L38) (Product # 704970) on 70-80% confluent U-2 OS cells treated with protein transport Inhibitor (1X for 4 hours). The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton X-100 for 15 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were stained with FGF23 Recombinant Rabbit Monoclonal Antibody (20H20L38) (Product # 704970, 1:200) in 0.1% BSA, incubated at 4 degree Celsiu... View More
产品信息
704970
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
20H20L38
抗原
Protein corresponding to human FGF23 (aa24-aa251)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets, an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia, a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: FGF; FGF-23; Fibroblast growth factor; Fibroblast growth factor 23; Phosphatonin; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor
基因别名: ADHR; FGF23; FGFN; HPDR2; HYPF; PHPTC; UNQ3027/PRO9828
UniProt ID: (Human) Q9GZV9
Entrez Gene ID: (Human) 8074
MAPK cascade
fibroblast growth factor receptor signaling pathway
regulation of phosphate transport
positive regulation of vitamin D 24-hydroxylase activity
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell differentiation
negative regulation of bone mineralization
cellular phosphate ion homeostasis
response to magnesium ion
phosphatidylinositol-3-phosphate biosynthetic process
vitamin D catabolic process
positive regulation of GTPase activity
cellular response to leptin stimulus
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
phosphatidylinositol phosphorylation
negative regulation of hormone secretion
phosphatidylinositol-mediated signaling
phosphate ion homeostasis
positive regulation of ERK1 and ERK2 cascade
cellular response to vitamin D
cellular response to interleukin-6
cellular response to parathyroid hormone stimulus
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
response to sodium phosphate
