应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
2 µg/mL | 查看2篇已发表文章 2篇已发表文章 |
免疫组化 (IHC) |
- | 查看1篇已发表文章 1篇已发表文章 |
免疫组化(石蜡) (IHC (P)) |
1:20-1:200 | - |
免疫细胞化学 (ICC/IF) |
- | 查看1篇已发表文章 1篇已发表文章 |
流式细胞分析 (Flow) |
- | 查看1篇已发表文章 1篇已发表文章 |
酶联免疫吸附实验 (ELISA) |
0.1-1.0 µg/mL | - |
免疫沉淀 (IP) |
2-5 µg | - |
产品规格 | |
---|---|
种属反应 |
Bovine, Chicken, Guinea pig, Human, Mouse, Rat |
已发表种属 |
Human, Rabbit |
宿主/亚型 |
Mouse / IgG1 |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
VBS-7 |
抗原 |
Bovine FGF Receptor 1 (flg) purified from bovine Coronary Venular Endothelial Cells (CVEC). |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
purified |
保存液 |
PBS |
内含物 |
0.1% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2533011 |
FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. FGFR1 has multiple isoforms and is a Type I membrane protein. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR1 binds both acidic and basic fibroblast growth factors and is involved in limb induction. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR-1, FGFR-2, FGFR-3 and FGFR-4.FGFRs are members of the tyrosine kinase family of growth factor receptors. At the mRNA level, FGFR1 is highly expressed in developing human tissues including the brain, vascular basement membrane and skin. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2.7.10.1; Basic fibroblast growth factor receptor 1; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD331 antigen; cek1 protein; cek1 protein precursor; FGF receptor-1; fgfr 1; FGFR-1; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome); fibroblast growth factor receptor 1-IIIc; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; MFR; N-sam; Proto-oncogene c-Fgr; Tyrosine kinase receptor CEK1
基因别名: AW208770; bFGF-R-1; BFGFR; c-fgr; CD331; CEK; CEK1; Eask; ECCL; FGFBR; FGFR-1; FGFR1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; Hspy; KAL2; MFR; N-SAM; OGD
UniProt ID: (Human) P11362, (Chicken) P21804, (Rat) Q04589, (Mouse) P16092
Entrez Gene ID: (Human) 2260, (Bovine) 281768, (Chicken) 396516, (Guinea pig) 100731156, (Rat) 79114, (Mouse) 14182
分子生物学功能:
transmembrane signal receptor