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产品信息
701179
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
14H10L9
抗原
Recombinant protein corresponding to amino acids 22-141 of human FGFR4
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532423
产品详细信息
This antibody is predicted to react with equine, mouse, rabbit and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
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生物信息学
蛋白别名: CD334; FGF Receptor; FGF Receptor 4; FGFR; FGFR-4; Fibroblast growth factor receptor 4; hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
基因别名: CD334; FGFR4; JTK2; TKF
UniProt ID: (Human) P22455
Entrez Gene ID: (Human) 2264
protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
heparin binding
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
transmembrane signal receptor
MAPK cascade
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of gene expression
regulation of extracellular matrix disassembly
regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
regulation of lipid metabolic process
phosphatidylinositol-3-phosphate biosynthetic process
glucose homeostasis
positive regulation of catalytic activity
positive regulation of GTPase activity
positive regulation of proteolysis
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
phosphate ion homeostasis
positive regulation of ERK1 and ERK2 cascade
regulation of bile acid biosynthetic process
response to bile acid
regulation of cholesterol homeostasis
positive regulation of DNA biosynthetic process
