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Invitrogen
FIS1 Polyclonal Antibody
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FIS1 Antibody (PA1-41082) in WB
Knockdown validation of FIS1 in A) human HeLa and B) mouse NIH 3T3 lysate. Samples were incubated in FIS1 polyclonal (Product # PA1-41082) using a dilution of 1:1000. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed in M17 cells stably transfected with vector only, Fis1 RNAi, Fis1 (Fis1wt OE) or left untransfected (negative control). The western blot data showed that M17 cells expressed Fis1 (Vector, Untransfected control) which could be knocked down by Fis1 RNAi. Cells transfected with Fis1 overexpressed Fis1. M17 is a hu... View More
产品信息
PA1-41082
应用
建议稀释比
已发表文章
产品规格
已发表种属
Cynomolgus monkey,
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 11-25 of human Fis1.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with rat, chimp, and canine based on sequence homology.
Suggested positive control: antigen standard for FIS1 (transient overexpression lysate), 3T3 or Hela whole cell lysate.
靶标信息
Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
