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Proteintech
FLI1 Polyclonal Antibody
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产品信息
11347-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FLI1 Fusion Protein Ag1899 (103-452 aa encoded by BC010115)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.53 mg/mL
规格
79.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NSYMDEKNG PPPPNMTTNE RRVIVPADPT LWTQEHVRQW LEWAIKEYSL MEIDTSFFQN MDGKELCKMN KEDFLRATTL YNTEVLLSHL SYLRESSLLA YNTTSHTDQS SRLSVKEDPS YDSVRRGAWG NNMNSGLNKS PPLGGAQTIS KNTEQRPQPD PYQILGPTSS RLANPGSGQI QLWQFLLELL SDSANASCIT WEGTNGEFKM TDPDEVARRW GERKSKPNMN YDKLSRALRY YYDKNIMTKV HGKRYAYKFD FHGIAQALQP HPTESSMYKY PSDISYMPSY HAHQQKVNFV PPHPSSMPVT SSSFFGAASQ YWTSPTGGIY PNPNVPRHPN THVPSHLGSY Y (103-452 aa encoded by BC010115)
靶标信息
The FLI1 (Friend Leukemia Integration 1) gene is located on chromosome 11q24.3 and belongs to the ETS (E26 transformation-specific) family of transcription factors. Structurally, FLI1 contains an ETS domain responsible for DNA binding and a pointed domain which facilitates protein-protein interactions. Functionally, it plays a critical role in the regulation of embryonic and hematopoietic development. It is also implicated in the pathogenesis of diseases such as Ewing's sarcoma, wherein a chromosomal translocation t(11;22)(q24;q12) forms the EWS-FLI1 fusion gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alternate; ETS transcription factor; Ewing sarcoma breakpoint region 2; Friend leukemia integration 1; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; Retroviral integration site protein Fli-1; similar to FLI-1; Transcription factor ERGB; unnamed protein product
基因别名: BDPLT21; EWSR2; FLI-1; FLI1; SIC-1; Sic1
UniProt ID: (Human) Q01543, (Mouse) P26323
Entrez Gene ID: (Human) 2313, (Mouse) 14247
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
winged helix/forkhead transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
hemostasis
blood circulation
organ morphogenesis
cell differentiation
megakaryocyte development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription from RNA polymerase II promoter
cellular process
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