Search Thermo Fisher Scientific
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Dimethylaniline monooxygenase [N-oxide-forming] 1; Dimethylaniline oxidase 1; Flavin-containing monooxygenase 1; FMO 1; Hepatic flavin-containing monooxygenase 1; Trimethylamine monooxygenase
基因别名: Fmo-1; Fmo1; RFMO1A
UniProt ID: (Rat) P36365
Entrez Gene ID: (Rat) 25256