Proteintech

FMRP Polyclonal Antibody

8 篇参考文献
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说明书
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FMRP Polyclonal Antibody

产品信息

13755-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
查看5篇已发表文章 5篇已发表文章

免疫组化 (IHC)

-
查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:500
-

免疫沉淀 (IP)

0.5-4.0 µg
-

不适用 (N/A)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

FMRP Fusion Protein Ag4697 (1-297 aa encoded by BC038998)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.24 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MEELVVEVR GSNGAFYKAF VKDVHEDSIT VAFENNWQPD RQIPFHDVRF PPPVGYNKDI NESDEVEVYS RANEKEPCCW WLAKVRMIKG EFYVIEYAAC DATYNEIVTI ERLRSVNPNK PATKDTFHKI KLDVPEDLRQ MCAKEAAHKD FKKAVGAFSV TYDPENYQLV ILSINEVTSK RAHMLIDMHF RSLRTKLSLI MRNEEASKQL ESSRQLASRF HEQFIVREDL MGLAIGTHGA NIQQARKVPG VTAIDLDEDT CTFHIYGEDQ DAVKKARSFL EFAEDVIQVP RNLVGLKI (1-297 aa encoded by BC038998)

靶标信息

FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: FMRP; fragile X mental retardation protein 1; fragile X mental retardation protein 1 homolog; Fragile X messenger ribonucleoprotein; Fragile X messenger ribonucleoprotein 1; MGC87458; Protein FMR-1

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基因别名: Fmr-1; FMR1; FMRP; FRAXA; POF; POF1

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UniProt ID: (Human) Q06787

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Entrez Gene ID: (Human) 2332, (Mouse) 14265

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功能
G-quadruplex RNA binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding microtubule binding poly(U) RNA binding translation repressor activity translation initiation factor binding RNA strand annealing activity poly(G) binding methylated histone binding siRNA binding miRNA binding RNA stem-loop binding identical protein binding protein homodimerization activity ribosome binding ion channel binding poly(A) RNA binding dynein binding protein heterodimerization activity mRNA 5'-UTR binding sequence-specific mRNA binding nucleic acid binding translation factor
参与通路
regulation of alternative mRNA splicing, via spliceosome positive regulation of receptor internalization mRNA processing cellular response to DNA damage stimulus glutamate receptor signaling pathway RNA splicing negative regulation of translation gene silencing by RNA positive regulation of histone phosphorylation cellular response to UV regulation of mRNA stability modulation by host of viral RNA genome replication positive regulation of translation negative regulation of translational initiation regulation of neurotransmitter secretion mRNA transport regulation of filopodium assembly positive regulation of filopodium assembly regulation of gene silencing by miRNA regulation of dendritic spine development positive regulation of dendritic spine development cellular response to hydroxyurea cellular response to virus regulation of neuronal action potential negative regulation of long term synaptic depression positive regulation of intracellular transport of viral material negative regulation of voltage-gated calcium channel activity positive regulation of proteasomal protein catabolic process positive regulation of mRNA binding negative regulation of synaptic vesicle exocytosis positive regulation of gene silencing by miRNA negative regulation of cytoplasmic translation positive regulation of response to DNA damage stimulus transport central nervous system development dendritic spine development
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