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Invitrogen
FOXO1 Polyclonal Antibody
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产品信息
PA1-25444
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, conjugated to KLH, corresponding to residues L(636) P N Q S F P H S V K T T T H S(651) of human FOXO1A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.4 mg/mL
规格
70 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PA1-25444 detects overexpressed FOXO1A from transfected human and mouse samples. PA1-25444 is expected to cross react with chicken (93% conserved) and porcine (100% conserved) due to sequence homology.
PA1-25444 has been successfully used in Western blot procedures.
The PA1-25444 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues L(636) P N Q S F P H S V K T T T H S(651) of human FOXO1A.
靶标信息
FOXO1 (FKHR, ForKHead Box 01) is a member in a subfamily of the forkhead homeotic gene family of transcription factors. Recent experiments have shown that FOXO1 can act as either a coactivator or a corepressor of nuclear receptor activity that is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein. Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma. Recent studies link the anti-tumor activity of FOXO1, the process of autophagy and myogenic growth and differentiation. FOXO1 is the main target of insulin signaling that regulated the metabolic homeostasis in response to oxidative stress. FOXO1 binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. FOXO1 is a regulator of redox balance, osteoblast numbers and controls bone mass. Further, FOXO1 orchestrates the endocrine function of the skeleton in regulating glucose metabolism, and suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, FOXO1 promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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