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Immunogen sequence: RVLLFNATGD RDPAALLKLL QPCQFDYAVF CPNLTEVSST GNADQQNFTV TLDQVLLRCL EHQQHWNHLD EEQASPDLWS APSPEPGGSA SLLL
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 74%.
Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs. Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis. Folylpoly-gamma-glutamate synthetase is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation. The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Folylpoly-gamma-glutamate synthetase; Folylpolyglutamate synthase, mitochondrial; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase
基因别名: FPGS
UniProt ID: (Human) Q05932
Entrez Gene ID: (Human) 2356
分子生物学功能:
ligase
metabolite interconversion enzyme