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This antibody recognizes isoform 1 (244 kDa), isoform 2 (80 kDa) and isoform 3 (43 kDa).
Immunogen sequence: SSSTTSGSF HLERRPLPSS MQLAVIRGDT LRGFDSTDLS QRKLRTRGNG KTVRPSSVYR NGTDIIYNYH GIVSLKLEDD SFPTHKRKAK VSIISQPQKT IKVAELPQAD KVESTTDSHF PRQDQLPSFP KNCTLELKGL FHFEEGIQKL YQCNGIAWKA WSPQTKDVED KSCPAGWHQH SGYCHILITE QKGTWNAAAQ ACREQYLGNL VTVFSRQHMR WLWDIGGRKS FWIGLNDQVH AGHWEWIGGE PVAFTNGRRG PSPRSKLGKS CVLVQRQGKW QTKDCRRAKP HNYGCSRKL (412-710 aa encoded by BC031064)
FREM1 is a member of the FRAS1-related extracellular matrix protein family and is thought to play a role in craniofacial and renal development. FREM1 functions as an extracellular matrix protein that is essential for epidermal adhesion during embryogenesis and may also participate in epidermal differentiation. It is recognized by cells in the embryonic skin and hair follicles through different members of the integrin family. Deficiency in the Fras1/Frem genes gives rise to the bleb phenotype, which is equivalent to the human hereditary disorder Fraser syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: extracellular matrix protein QBRICK; FRAS1-related extracellular matrix protein 1; Protein QBRICK; RP11-265B7.2
基因别名: BNAR; C9orf143; C9orf145; C9orf154; FREM1; MOTA; TILRR; TRIGNO2
UniProt ID: (Human) Q5H8C1
Entrez Gene ID: (Human) 158326